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3 Department of Nutrition and Exercise Sciences and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 4 Department of Nutrition and Health Sciences, University of Nebraska at Lincoln, Lincoln, NE 68588
The American Society for Nutrition hosted a symposium entitled Nutrients and Epigenetic Regulation of Gene Expression at the Experimental Biology meeting on April 20, 2009, in New Orleans, LA. The symposium was cochaired by Emily Ho from Oregon State University and the Linus Pauling Institute, and Janos Zempleni from the University of Nebraska at Lincoln. The goal of this symposium was to highlight the interactions among nutrients, epigenetics, and disease susceptibility. The symposium featured 4 speakers, each presenting novel insights into mechanisms by which nutrients participate in gene regulation. Janos Zempleni elucidated mechanisms by which the covalent binding of biotin to histones represses transposable elements, thereby enhancing genome stability. Emily Ho shared valuable insights into bioactive food compounds that inhibit histone deacetylases. James Kirkland from the University of Guelph in Canada talked about a niacin-dependent poly(ADP-ribosylation) of histones, an epigenetic mark that is not currently being given full consideration in nutrition. Patrick Stover from Cornell University described the interrelationships among 1-carbon metabolism, DNA methylation, gene silencing, and their influence in the etiology of folate-related pathologies. All 4 presentations were videotaped and can be viewed online (www.nutrition.org).
* To whom correspondence should be addressed. E-mail: emily.ho{at}oregonstate.edu and jzempleni2{at}unl.edu.
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  J. B. Kirkland Niacin Status Impacts Chromatin Structure J. Nutr., December 1, 2009; 139(12): 2397 - 2401. [Abstract] [Full Text] [PDF]
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J. Zempleni, Y. C. Chew, B. Bao, V. Pestinger, and S. S. K. Wijeratne Repression of Transposable Elements by Histone Biotinylation J. Nutr., December 1, 2009; 139(12): 2389 - 2392. [Abstract] [Full Text] [PDF]
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E. Ho, J. D. Clarke, and R. H. Dashwood Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention J. Nutr., December 1, 2009; 139(12): 2393 - 2396. [Abstract] [Full Text] [PDF]
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P. J. Stover One-Carbon Metabolism-Genome Interactions in Folate-Associated Pathologies J. Nutr., December 1, 2009; 139(12): 2402 - 2405. [Abstract] [Full Text] [PDF]
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